MicFunPred which only uses a set of core genes predicted at genus level to derive imputed metagenomes, thereby minimizing false positive predictions. On simulated datasets, MicFunPred showed the lowest False Positive Rate (FPR) with mean Spearman’s correlation of 0.89 (SD=0.03) while on 7 different real datasets the mean correlation was 0.75 (SD=0.08). MicFunPred was found to be faster with low computational requirements and performed better or comparable, when compared with other tools.
Webserver: http://micfunpred.microdm.net.in/
Standalone: https://github.com/microDM/MicFunPred
Intestinal microbiome is shown altered structure in patients with heart failure (HF) and that these changes may play a modulatory role in disease progression. Here, we studied effect of heart failure on gut microbiome and circulating metabolome of induced mice after 0, 7, 17 and 42 days.
Collaborator: Ashraf Y. Rangrez, Postdoc at Dept of Molecular cardiology, University hospital Kiel
Here we have We compared gut microbiota, gut gene expression and SCFA composition in the wild-type (DiO Controls) and NPS +/- (DiO-resistant) mice using 16S rRNA sequencing, real-time quantitative PCR (RT-qPCR) and gas chromatography-mass spectrometry (GC-MS) respectively.
Collaborator: Dr. Anand Hardikar, Associate Professor, School of Medicine, Western Sydney University.